The swelling and degradation of the optimized beads were influenced by pH of test mediums. The in vitro dissolution of these beads showed prolonged sustained release of aceclofenac over 6 h, which followed first‐order model with anomalous (non‐Fickian) diffusion mechanism. The developed beads were characterized by scanning electron microscope, Fourier transform‐infrared spectroscopy, and powder X‐ray diffraction.
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The apparent viscosity values of yogurts were recorded using RHEOCALC 32 Application Software (Brookfield Engineering Laboratories Inc., Middleboro, MA, USA). Description: The LAN9218(i) is a full-featured, single-chip 10/100 Ethernet controller designed for embedded applications where performance, flexibility, ease of integration and system cost control. The results were measured in mPas, after 35 s of shearing, paying attention to the torque values being between 10 and 100.
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The average size of all these beads ranged from 1.08 ± 0.08 to 1.48 ± 0.18 mm. Network Cards and Network Controllers - 10/100 Base-T/TX Ethernet Controller with 32 Bit Interface - LAN9218 Supplier: Microchip Technology, Inc. The optimized beads showed drug encapsulation efficiency of 88.26 ± 3.78% and cumulative drug release of 26.28 ± 1.21% after 6 h of dissolution. The effects of sodium alginate and cationized starch amounts as independent process variables on drug encapsulation, and drug release were optimized using central composite design. Sustained aceclofenac release cationized starch–alginate beads were developed through ionotropic gelation. Malakar, Jadupati Nayak, Amit Kumar Das, Arindam Modified starch (cationized)–alginate beads containing aceclofenac: Formulation optimization using central composite design Modified starch (cationized)–alginate beads containing aceclofenac: Formulation optimization.
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